Anti Cancer Drugs

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• Gefitinib, indicated in Europe for the treatment of grown up with locally advanced or metastatic NSCLC with activating mutations of EGFR-TK.
• Gefitinib Tablets (Astra Zeneca) 250mg

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• Nufil sfs contains Filgrastim which is a granulocyte colony-stimulating factor (G-CSF) analog used to stimulate the proliferation and differentiation. It is produced by recombinant DNA technology.
• The gene for human granulocyte colony-stimulating factor is inserted into the genetic material of Escherichia coli. The G-CSF then produced by E. coli is only slightly different from G-CSF naturally made in humans.

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Imutrex contains Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more powerful and toxic antifolate aminopterin starting in the 1950s, and the two should not be confused with each other.PharmacodynamicsPharmacokinetics

Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of reduced folates, and thymidylate synthetase, resulting in inhibition of purine and thymidylic acid synthesis.

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We are recognized as the foremost exporter, wholesaler and supplier of Soranib - Sorafenib 200mg Tablets (Cipla). These tablets are specifically formulated for the treatment of primary kidney cancer and major liver cancer. Furthermore, we sourced these tablets from the reliable vendors of the industry who utilize optimum quality chemical substances in the processing process. High effectiveness, accurate composition, purity and safe consumption are the quality attributes, which make these tablets highly demanded in the national as well as international market.

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Sorafenat is a cancer chemotherapeutic medication

• Sorafenat (sorafenib 200mg) interferes with the growth of cancer cells and slows their growth and spread in the body
• Sorafenat (sorafenib 200mg) is used to treat a type of kidney cancer called advanced renal cell carcinoma
• It is also used to treat liver cancer
• Sorafenat (sorafenib 200mg) may also be used for other purposes not listed in this medication guide

• Stop using Sorafenat (sorafenib 200mg) and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat

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Afinitor everolimus 10mg is used to treat kidney cancer. It is also used to treat certain tumors in the brain. It works by slowing or stopping the growth of cancer cells.

• Afinitor (everolimus) 10mg is used to treat kidney cancer
• It is also used to treat certain tumors in the brain
• It works by slowing or stopping the growth of cancer cells

• If you have any questions, ask your doctor or pharmacist
• Take Afinitor (everolimus) 10mg by mouth with or without food, usually once daily or as directed by your doctor
• Swallow Afinitor (everolimus) 10mg whole with a glass of water
• Do not crush, chew, or break the tablets
• Dosage of Afinitor (everolimus) 10mg is based on your medical condition, interacting drugs, and response to treatment
• Use Afinitor (everolimus) 10mg regularly to get the most benefit from it
• To help you remember, take it at the same time each day
• Do not increase your dose or take Afinitor (everolimus) 10mg more often without your doctor's approval
• Your condition will not improve any faster and the risk of serious side effects may be increased.

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Generic for Trisenox (Arsenic Trioxide) is a cancer medication used to treat a type of cancer called acute promyelocytic leukemia or APL (blood and bone marrow cancer). Arsenic Trioxide belongs to a class of medications called anti-neoplastics. This injection medication works by slowing the growth of cancer cells in the body.

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Genricv for Velcade (Bortezomib) is used treating relapsed multiple myeloma and mantle cell lymphoma.

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How does P-Carzine (Procarbazine HCL) work:

P-Carzine (Procarbazine HCL) is used as a treatment during the stages 3 and 4 of Hodgkin lymphoma. P-Carzine is an anti-neoplastic drug that is commonly used alongside other medication to inhibit the growth of cancer cells. Be aware that this medication also effects non-cancerous cells and use will likely have side effects.

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(Oxaliplatin) is an anti-cancer chemotherapy injection used to treat advanced cancer of the colon or rectum (metastatic colorectal cancer). Oxaliplatin is used in combination with other anti-cancer drugs. This drug works by stopping the multiplication of the cancer cells.

Recommended Dosage - Discount Prescription Drug Generic for EloxatinThe dosage of Generic for Eloxatin prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.We are instrumental in offering our clients with Oxaliplatin that is mainly used to treat cancer chemotherapy. It is a coordination complex, which is a platinum-based drug, usually classified as alkylating agents. Actually, this is not from the alkylating groups, but its functions as similar as its mechanism. We pack all our products using hygienic and safe packaging material to retain its effectiveness.

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TYKERB is a prescription medicine used with another prescription medicine.

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These Generic - Dasanat Tablet - Dasatinib 50mg manufactured by Natco Pharma Limited also known as generic is used for the treatment of myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It helps in slowing the growth and spread of cancer cells in the body. Dasanat (Dasatinib Tablet) blocks proteins that lead to rapid growth of certain types of leukemia cells. As Dasanat (Dasatinib Tablet) can lead to lowering of blood cells that help the body to fight infections, the patient using this medication may get more prone to bleeding from an injury or may get sick from being around others who are ill. You should refrain from coming in contact with people who have flu, colds, or other contagious illnesses. It is prescription medication.

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Alphalan contains Melphalan it is used in multiple myeloma,breast carcinoma,advanced ovarian carcinoma,polycythaemia vera, Neuroblastoma, Melanoma, soft tissue sarcoma.

Chemotherapy primarily refers to the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen. Certain chemotherapy agents also have a role in the treatment of other conditions, including ankylosing spondylitis, multiple sclerosis, Crohn's disease, psoriasis, psoriatic arthritis, rheumatoid arthritis and scleroderma.The most common chemotherapy agents act by killing cells that divide rapidly, one of the main properties of most cancer cells. This means that chemotherapy also harms cells that divide rapidly under normal circumstances: cells in the bone marrow, digestive tract, and hair follicles. This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss).

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• Altretamine is a cancer (antineoplastic) medication. Altretamine interferes with the growth of cancer cells and slows their growth and spread in the body.
• Altretamine is used to treat cancer of the ovaries.
• Altretamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Cantret (altretamine)?

Altretamine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of altretamine including:

• allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat); neurologic problems (mood disorders, altered consciousness, weakness, dizziness, vertigo); and others. Talk to your doctor about the possible side effects from treatment with altretamine.

What should I discuss with my healthcare provider before taking Cantret (altretamine)?

Before taking altretamine, tell your doctor if you have:

• Any nervous system (brain and nerves) problems; or
• bone marrow problems.
• You may not be able to take altretamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
• Altretamine is in the FDA pregnancy category D. This means that altretamine is known to cause birth defects in an unborn baby. Do not take altretamine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with altretamine. It is not known whether altretamine passes into breast milk. Do not take altretamine without first talking to your doctor if you are breast feeding a baby.

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Why Aprecap(Aprepitant ) is prescribed (Indications) :

This medication is an antiemetic, prescribed for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

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An active ingredient of Tamodex is Tamoxifen which is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women.

Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.

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It is an antimetabolite, prescribed for breast cancer and colorectal cancer. It prevents the growth of cancer cells.

Capecitabine harms cancer cells causing their death

Common side effects of Capecitabine :
Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. - Loose stools. - Feeling tired or weak. - Swelling in the feet or hands.

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Bendit This contains bendamustine and is effective in treating chronic lymphocytic leukemia as well as non-hodgkins lymphoma. It functions by damaging the dna of the cancer cells and hence resulting in the growth of the cancer cells.

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dosage: ideally, the recommended dose is 100 mg/ml, administered intravenously over 30 minutes on day 1 and 2 of a 28-day cycle (up to 6 cycles) overdose: symptoms of overdose associated with the medicine may include rapid, or pounding heartbeat, loss of coordination, seizures, severe drowsiness, tremor and difficulty in breathing.

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Decita Injection 50mg. Used for the treatment of cancer, this injection is highly acclaimed among our clients who are situated across the nation. This injection is formulated by our vendors' experts under the most hygiene conditions using quality tested chemicals and modish technology. In order to keep its effectiveness for long time period, this injection is well packed with the use of qualitative material. 

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• Accurate composition
• Effective
• No side effects

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Oxitan contains Oxaliplatin.

Oxitan is a platinum-based cancer chemotherapy drug.Oxaliplatin is used in combination with other anticancer drugs to treat advanced cancer (not cured by other drugs) of colon, rectum or as additional treatment following surgery to remove tumor in colon.This medicine contains oxaliplatin and is also prescribed for the treatment of late stage ovarian cancer.

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Cytotam contains Tamoxifen which is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women.

Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.

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This medication is an antiestrogen, prescribed for breast cancer. It is also used for infertility, gynecomastia, ductal carcinoma either alone or with other medications. It blocks the actions of estrogen.
Tamoxifen stops estrogen from feeding estrogen-dependent cancer cells. This lowers the chance for spread of the cancer. It helps start egg release (ovulation).

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Xtrant is a prescription drug and should be used under proper medical guidance and advice. Do not share the medicine with others, since they may be suffering from a problem that is not effectively treated by this drug.

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Cytodrox is used to treat certain types of cancer (melanoma, chronic myelocytic leukemia, cancer of the ovary, and primary skin cancer of the head and neck) or sickled red blood cells. Active ingredient of this drug. The exact mechanism of its action is unknown, it is supposed that it is cell cycle specific for the S phase of cell division, it interfere with synthesis of DNA, with no effect on synthesis of RNA or protein.

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Canmab Injection manufactured by Biocon Pharmaceuticals and contains Trastuzumab as active ingredient in it.
Trastuzumab Injection is used for the treatment of breast cancer alone or in combination with other medicines. It is also used in combination with other medicines to treat certain types of stomach or esophagus cancer in certain patients.

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Evertor tablets contain the active ingredient everolimus, which is a type of medicine known as a protein kinase inhibitor. It works by interfering with the pathways that signal certain cancer cells to grow.The way that cells in the body work and grow is regulated by various enzymes called protein kinases. These enzymes can be found in certain receptors on the surface of cells that are involved in the growth and spread of cancer cells.In cancerous cells, the kinases make the cells grow and multiply abnormally. They also stimulate nearby blood vessels to grow into the tumour. The new blood vessels allow the cancer cells to grow and multiply by supplying them with oxygen and nutrients. They also allow the cancerous cells to spread into other areas of the body through the blood circulation.Everolimus works by attaching to a certain protein inside the cancer cells and blocking the action of a protein kinase called mammalian target of rapamycin (mTOR). This stops the signals that tell the cancer cells to grow and multiply. It also stops blood vessels growing into the tumour. This reduces the tumour’s blood supply and with it, its supply of oxygen and nutrients. Both these effects stop the tumour from growing.

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Imatinib is a drug used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt. It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and other cancers.

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Bortezomib is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma.

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Suninat contains Sunitinib Malate.

Suninat is a cancer medicine that helps the body slow down the growth and reproduction of certain cells, including tumor cells. It is used to treat certain types of advanced or progressive tumors of the digestive system, the pancreas, or the kidneys.
Cancer cells have abnormal rates of growth and multiply at rates that are different than normal cells.

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Alkeran contains Melphalan.

Alkeran is used to treat certain types of cancer (multiple myeloma, ovarian cancer). Melphalan belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

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Cervarix is a vaccine indicated for the prevention of the following diseases caused by oncogenic human papillomavirus (HPV) types 16 and 18:

•Cervical cancer,
•Cervical intraepithelial neoplasia (CIN) grade 2 or worse and adenocarcinoma in situ, and
•Cervical intraepithelial neoplasia (CIN) grade 1. (1.1) CERVARIX is approved for use in females 9 through 25 years of age. Limitations of Use and Effectiveness (1.2)
•Cervarix does not provide protection against disease due to all HPV types. (14.3)
•Cervarix has not been demonstrated to provide protection against disease from vaccine and non-vaccine HPV types to which a woman has previously been exposed through activity. (14.2)

Dosage And Administration:
Three doses (0.5-mL each) by intramuscular injection according to the following schedule: 0, 1, and 6 months.

(2.2) Dosage Forms And Strengths:
Single-dose prefilled syringes containing a 0.5-mL suspension for injection. (3)

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Physical State Liquid

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Ristova belongs to a group of cancer drugs known as monoclonal antibodies|.

Monoclonal antibodies recognise and lock onto specific proteins on the surface of cancer cells. This helps the body's immune system to recognise the cancer cells and destroy them. Monoclonal antibodies are sometimes called targeted therapies because they target cancer cells.

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Nolvadex contains Tamoxifen which is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women.

Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.

Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."

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Erlocip (Erlotinib hydrochloride) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is marketed in the United States by Genetech and OSI Pharmaceuticals.

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Geftinat (Gefitinib) is used to treat adults with non-small cell lung cancer.

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We are recognized as the foremost exporter, wholesaler and supplier of Soranib - Sorafenib 200mg Tablets (Cipla). These tablets are specifically formulated for the treatment of primary kidney cancer and major liver cancer. Furthermore, we sourced these tablets from the reliable vendors of the industry who utilize optimum quality chemical substances in the processing process. High effectiveness, accurate composition, purity and safe consumption are the quality attributes, which make these tablets highly demanded in the national as well as international market.

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Leucovorin contains Folinic acid, generally administered as calcium folinate is an adjuvant used in cancer chemotherapy involving the drug methotrexate.

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Armotraz contains Anastrozole 
Armotraz tablets 1mg are used to treat breast cancer in postmenopausal women, as first line therapy for early, advanced or metastatic breast cancer. Armotraz tablets 1mg are also used as additional treatment for early breast cancer in conjunction with other breast cancer treatment (tamoxifen) or if tamoxifen therapy has not helped prevent progression of the tumour.

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We have carved a niche in offering a supreme quality Pegfilgrastim. The offered Pegfilgrastim is is an amino acid, prescribed for decreasing the incidence of infection, drug induced febrile neutropenia, in patients who are receiving myelosuppressive anti-cancer drugs. This Pegfilgrastim is provided in air tight packing on numerous grades as per customer’s requirements. Our provided Pegfilgrastim is stringently tested on various parameters to ensure its quality.

Features:

• Effectiveness
• Longer shelf life
• No allergic reaction

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• Imupeg(Pegfilgrastim Injection) is an amino acid, prescribed for decreasing the incidence of infection, drug induced febrile neutropenia (decreased number of neutrophils), in patients who are receiving myelosuppressive anti-cancer drugs.

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Dacarbazine belongs to the group of cancer-fighting medications called antineoplastics. It kills cancer cells by interfering with their growth and reproduction. Dacarbazine is used alone or in combination with other antineoplastic medications to treat metastatic malignant melanoma (a type of skin cancer).

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Fulvestrant 500 mg, a treatment option for postmenopausal women with hormone receptor-positive metastatic breast cancer.

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Anastrozole is used in the treatment of early-stage breast cancer in post-menopausal women. It is also used in the treatment of advanced (that has spread within the breast or to other parts of the body) breast cancer in post-menopausal women previously treated with drug tamoxifen.
Anastrozole is an aromatase inhibitor. It works by lowering blood estradiol concentrations, which may decrease the size and growth of the tumor.

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Tamoxifen Citrate, an anticancer drug, is given to treat breast cancer in women and men.

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Alimta contains Alimta Pemetrexed.
(Pemetrexed) is a chemotherapy injection used to treat two types of lung cancers: non-small cell lung cancer and mesothelioma, a rare cancer associated with asbestos exposure. This cancer medication works by slowing the growth and spread of cancer cells in the body.

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Epithra is an anthracycline drug used for chemotherapy. It is marketed by Pfizer under the trade name Ellence in the US.

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Gefticip is a prescription drug and should be used under proper medical guidance and advice. Do not share the medicine with others, since they may be suffering from a problem that is not effectively treated by this drug.

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Pemetrexed is a chemotherapy injection used to treat two types of lung cancers: non-small cell lung cancer and mesothelioma, a rare cancer associated with asbestos exposure. This cancer medication works by slowing the growth and spread of cancer cells in the body.

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Arimidex, ingredient anastrozole, is an aromatase inhibitor used to treat breast cancer in women after menopause.
Description:

Follow the directions for using this medicine provided by your doctor

• This medicine may be taken on an empty stomach or with food
• Store this medicine at room temperature in a tightly-closed container, away from heat and light
• If you miss a dose of this medicine, take it as soon as possible
• If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule
• Do not take 2 doses at once

Cautions:

• Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks
• Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine
• Use a non-hormonal method of birth control if you are a woman capable of becoming pregnant
• This medicine has been shown to cause harm to the human fetus
• If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy
• It is unknown if this drug is excreted in breast milk
• If you are or will be breast-feeding while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.

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Oncovac contains BCG Vaccine for percutaneous use, is an attenuated, live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain ofMycobacterium bovis.1 The TICE® strain used in this BCG Vaccine preparation was developed at the University of Illinois from a strain originated at the Pasteur Institute.

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Blaztere strengthens bone and is primarily used to treat osteoporosis. To treat Paget's disease of the bone (disease causing enlarged and misshapen bones due to abnormal bone destruction and growth) in adults.
Blaztere is used to treat bone diseases that occur together with certain types of cancers. Certain types of cancers cause the calcium in your bones to leak out into the bloodstream.

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Pemnat contains pemetrexed and belongs to a class of medications called antifolate antineoplastic agents.
Indication
Pemnat may also be used for the treatment of non-small cell lung cancer.Pemnat is used with for the treatment of malignant pleural mesothelioma (a type of cancer that affects the inside lining of the chest cavity) who cannot be treated with surgery.

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Peg grafeel contains Pegfilgrastim manufactured By Dr Reddy.
NOTE : Peg grafeel is a prescription drug and should be used under proper medical guidance and advice. Do not share the medicine with others, since they may be suffering from a problem that is not effectively treated by this drug.

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Honvan (120mg) Zydus Cadila Healthcare Ltd

Salt Information

Fosfestrol (120 Mg) Typical Usage

Adjunct in the treatment of opiod dependence, Breast cancer, Dermatomyositis, Nasopharyngeal fibromas, Oncology, Parathyroid carcinoma, Plasmacytomas, Prostatic cancer, Rheumatoid arthritis.

Side Effects

Dizziness, Anorexia, Diarrhea, Fever, Nausea and vomiting, Perineal pruritis, Perineal pain.

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Clokeran (Chlorambucil)is used for Breast cancer, chronic lymphocytic leukaemia, hodgkin's disease, leukaemia, macroglobulinemia, non-hodgkin's lymphoma, ovarian cancer, waldenstrom's macroglobulinaemia.

Chlorambucil work by three different mechanisms:

1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA.

2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

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Decotin(Oxaliplatin) is a platinum-based cancer chemotherapy drug. These drugs are usually classified as alkylating agents, although they are not capable of actually adding alkyl groups to DNA and simply work by a similar mechanism.

Oxaliplatin is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX for the treatment of colorectal cancer. Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin or by Medac GmbH under the trademark Oxaliplatin Medac. There are generic equivalents on the market now.

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Anticancer drugs

Anticancer drugs are used to control the growth of cancerous cells.

Cancer is commonly defined as the uncontrolled growth of cells, with loss of differentiation and commonly, with metastasis, spread of the cancer to other tissues and organs.

Cancers are malignant growths. In contrast, benign growths remain encapsulated and grow within a well-defined area. Drug therapy is used when the tumor has spread, or may spread, to all areas of the body.

Description

Several classes of drugs may be used in cancer treatment, depending on the nature of the organ involved. For example, breast cancers are commonly stimulated by estrogens, and may be treated with drugs that inactivate the hormones. Majority of antineoplastic drugs act by interfering with cell growth. Since cancerous cells grow more rapidly than other cells, the drugs target those cells that are in the process of reproducing themselves. As a result, antineoplastic drugs will commonly affect not only the cancerous cells, but others cells that commonly reproduce quickly, including hair follicels, ovaries and testes, and the blood-forming organs.

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Hycamtin binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. This ternary complex interferes with the moving replication fork, which leads to the induction of replication arrest and lethal double-stranded breaks in DNA. The formation of this ternary complex eventually leads to apoptosis (programmed cell death).

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Alkeran(Melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent that is active against selected human neoplastic diseases.

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Epithra is an anthracycline drug used for chemotherapy. It is marketed by Pfizer under the trade name Ellence in the US.

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Cytotam contains Tamoxifen which is an antagonist of the estrogen receptor in breast tissue. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer, although aromatase inhibitors have been proposed for postmenopausal women.

Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.

Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."

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Abiraterone acetate is used for treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with prednisone, a steroid. Abiraterone is a type of hormone therapy.

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Dacilon (Doctanomycine) is used to treat Wilms tumour, rhabdomyosarcoma, carcinoma of testis and uterus.

Dactinomycin binds to the guanine portion of DNA forming a complex which interferes with DNA and RNA synthesis as well as protein synthesis. It may also enhance the cytotoxic effects of radiotherapy.

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Oncotrex(Methotrexate), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more powerful and toxic antifolate aminopterin starting in the 1950s, and the two should not be confused with each other.

PharmacodynamicsPharmacokinetics

Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of reduced folates, and thymidylate synthetase, resulting in inhibition of purine and thymidylic acid synthesis.

Absorption
Rapidly absorbed from the GI tract at low doses, higher doses are less well absorbed. Rapidly and completely absorbed after IM doses. Peak plasma concentrations after 1-2 hours (oral), 30-60 minutes (IM).

Distribution
Tissues and extracellular fluids; crosses the blood-brain barrier and placenta; enters breast milk. Small amounts in saliva and breastmilk. 50% bound to plasma proteins. Bound as polyglutamate conjugates, bound drug may remain in the body for several months, particularly in the liver .

Metabolism
Partly by intestinal flora. Does not undergo significant metabolism at low dose therapy; 7-hydroxy metabolite is detected at high-doses.

Excretion
Primarily via urine; small amounts in bile, faeces. Some evidence of enterohepatic recirculation. Interindividual variation exists, patients with delayed clearance are at an increased risk of toxicity.

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